My 4.5 year old daughter has a problem with amines, she started wetting her pants at about 2.5 years old (after being dry and self toilet trained for 6 months without accidents), it got so bad we were up at the hospital at one point as she was urgently urinating every 30-45 mins for a few days, it was horrible.

I went to Drs numerous times about it over a year, sometimes we would be in the Drs office and her urgency to urinate was so great that we had to duck out to use the toilet mid-appointment, then after the appointment we would get to the car and she would have to urgently go again but going back to the clinic was too far for her to hold it so she would have to wee in a garden next to the car. Our Dr put it down to her being constipated and it pushing on her bladder and kept telling me kids don't need to be toilet trained until they are 4, just keep training her, even though I knew this was not the problem, she knew how to go to the toilet and we did have weeks when she was dry and weeks when she wasn't so I didn't think it was a "lazy" issue. I tried to get a referral numerous times to our local hospital but I was told we have to wait until after she is 4 because it isn't classed as a problem until then. Daycare also mentioned to me that they way she drank and urinated looked similar to a child they had that had diabetes but this was ruled out.

She always had long bouts of screaming since she was a baby, along with what felt like constant nappy rash. Some time after she was 2 she started getting hives on her face when she had soy sauce (sushi is her favourite food and we would have it a few times a month). If she got the sauce on her fingers and scratched herself she would then have hives where her fingers had touched. I had gone to numerous Drs and a pediatrician concerned about her screaming sessions and the only thing that came up in the tests was low iron. I also asked the Dr about the soy sauce and it giving her hives and I was told if it doesn't bother her, keep giving it to her, however the tantrums were so frequent we didn't think it was bothering her and I trusted the Dr's advice.

Then when she was 3.5 years old we had had a few weeks break from eating sushi and then she ate some with soy sauce. She then got tired shortly after, hopped into bed and wanted to go to sleep, she got hives around her mouth. It was like a switch had gone on where she was then defiant and had to say no to everything that was asked of her, she was very angry and our little girl even spat at me. She then started urinating very frequently and was busting to go, this lasted a few days and I also noticed she was mixing some of her words up like she was confused. She wasn't back to her normal self until about 1.5-2 weeks later. Finally with all these problem symptoms happening at once after we had had a bit of a good run, the penny dropped that it was the food doing this to her.

She has since been tested for a skin prick soy allergy which came back negative and the nurse at the allergy clinic suggested an intolerance to amines. I tested her skin with 4 different types of soy sauce to see if it was ribo rash causing this (635 flavour enhancer) but she got hives from all four sauces even the one with very simple ingredients in it.

She still has sushi but without the soy sauce and since we cut the out of her diet she hasn't wet her pants, she hasn't had urine urgency at home or at daycare and her long screaming fits reduced dramatically from a few times a month to about 2 a year. Her iron levels are also at a normal level. I have since pointed out to the medical professionals we saw that it was the soy sauce that was the culprit and I'd read an article that said it can irritate the bladder however none of them had heard of such a thing. I do wish we had gotten the proper help earlier on. I look back at how often she screamed, how irritated she must have been and the hours we spent trying to calm her down, that all cleared up by simply removing soy sauce and reducing high amine foods.

Here is a photo of her face after having soy sauce and her lower back after it dripped on her fingers and she scratched herself - Melinda

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