Ever since I became pregnant with my first child 13 yrs ago, I have reacted to 220 sulphites.  Especially in red wine, well actually any wine and a range of alcoholic drinks.  Within half an hour I start sneezing heavily as if I am developing a cold.  My throat then feels sore and my face reddens and becomes puffy.  I have also linked 220 to eczema, which I have struggled with all my life. After refraining from 220, my incurable eczema vanished almost completely with in days. Beware though!  I have switched to preservative free wines. Happs is fine but some of the others which claim to be preservative-free still affect me. Reading the labels more closely, some only claim to have NO PRESERVATIVES ADDED. These wines still make me react. - Jenny, NSW