I first noticed the annatto/IBS connection (bad smelling gas, diarrhea, loose stools) with my 3 year old son specifically with processed cheese singles, so I try to keep him away from those and generally don't have a problem, or if so, it is only small. Recently, we were away for almost a week, and when we came back, he started taking these "gummy vites" children's vitamins ("all natural" and sure enough colored with all natural annatto) he hadn't had for some time, and it was like a switch went off and the symptoms were back full force. - Anna, US