I developed 202 intolerance in my mid 40s and now avoid 202 like the plague as it gives me pain in the splenic flexure of my descending colon, sometimes inflaming the whole descending colon. I suffered a barium meal, and no consult with any doctor delivered me an answer to my difficulty. Elimination of 202 solved a range of unexplained symptoms. I picked up the problem by timing my recurrent pain 1.5 hours after spreading margarine on my toast. - by email, New Zealand